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組蛋白的甲基化、乙酰化和磷酸基化等翻譯后修飾(PTM)是調(diào)節(jié)基因表達(dá)調(diào)控、DNA修復(fù)、染色體凝縮和精子形成的關(guān)鍵步驟。目前,已經(jīng)確認(rèn)許多蛋白能夠形成復(fù)合物,起到調(diào)節(jié)組蛋白修飾的作用。 這些組蛋白修飾復(fù)合物的功能變化被認(rèn)為破壞了組蛋白標(biāo)記的結(jié)構(gòu)和水平,從而解除了基于核染色質(zhì)的過程控制,最終導(dǎo)致致癌轉(zhuǎn)化和癌癥的發(fā)展。與此一致的是,組蛋白PTM的異常模式與大量的人類惡性腫瘤有關(guān)。

眾所周知,組蛋白的翻譯后修飾(PTM)在表觀遺傳調(diào)控中發(fā)揮重要作用,研究組蛋白PTM過程中抗體是很重要的一環(huán),組蛋白PTM的抗體是表觀遺傳學(xué)研究(如染色質(zhì)免疫沉淀(ChIP)、免疫染色和免疫印跡)中的關(guān)鍵元素。然而,目前市面上許多組蛋白PTM抗體不能特異識別預(yù)定目標(biāo)。今天小艾給大家?guī)碇放芌ockland專利的組蛋白修飾相關(guān)抗體——Epi-Plus?系列抗體,期望Epi-Plus?憑借其無與倫比靈敏度和特異性給廣大科研工作者組蛋白PTM研究帶來新助力。
Rockland Epi-Plus?特點及優(yōu)勢:
Rockland的高特異性Epi-Plus?系列抗體可識別經(jīng)過修飾的組蛋白和相關(guān)的細(xì)胞靶點,并通過多種檢測方法進(jìn)行驗證。Epi-Plus?抗體對這種修飾是特別靈敏和特異的,并且對相同位點或該蛋白其他氨基酸的其他修飾沒有交叉反應(yīng)。免疫熒光(IF)、免疫沉淀(IP)、染色質(zhì)免疫沉淀(ChIP)、免疫組化(IHC)和蛋白印跡(WB)的分析驗證了Epi-Plus?抗體的有效性。
Histone 3 K4 甲基化相關(guān)抗體:
| 貨號 | 名稱 | 規(guī)格 |
| 600-401-I57 | Anti-Histone H3 [Monomethyl Lys4] (RABBIT) Antibody | 50ug |
| 600-401-I58 | Anti-Histone H3 [Dimethyl Lys4] (RABBIT) Antibody | 50ug |
| 600-401-I59 | Anti-Histone H3 [Trimethyl Lys4] (RABBIT) Antibody | 50ug |
Epi-Plus? 其他組蛋白修飾抗體推薦:
| 貨號 | 名稱 | 規(guī)格 | 種屬反應(yīng) |
| 600-401-I52 | Histone H3 R2me1 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I53 | Histone H3 R2me2a Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I54 | Histone H3 K4me1/pT3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I55 | Histone H3 K4me2/pT3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I56 | Histone H3 pT3/K4ac Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I57 | Histone H3 K4me1 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I58 | Histone H3 K4me2 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I59 | Histone H3 K4me3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I60 | Histone H3 K4ac Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I61 | Histone H3 K4me1/pT6 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I62 | Histone H3 K4me3/pT6 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I63 | Histone H3 pT6 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I64 | Histone H3 K9me1/pT6 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I65 | Histone H3 K9me2/pT6 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I66 | Histone H3 K9me3/pT6 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I67 | Histone H3 R8me2a Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I68 | Histone H3 R8me2s Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I69 | Histone H3 K9me1 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I70 | Histone H3 K9me2 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I71 | Histone H3 K9me3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I72 | Histone H3 K9ac Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I73 | Histone H3 K9ac/K14ac Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I74 | Histone H3 pS10 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I75 | Histone H3 pS10/pT11 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I76 | Histone H3 pT11 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I77 | Histone H3 R17me2a Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I78 | Histone H3 K18me1 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I79 | Histone H3 K18me2 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I80 | Histone H3 K18me3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I81 | Histone H3 K18ac Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I82 | Histone H3 K23ac Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I83 | Histone H3 pS28 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I84 | Histone H3 K27me3/pS28 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I85 | Histone H3 R2me2s/K4me2 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I86 | Histone H3 K36me1 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I87 | Histone H3 K36me2 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I88 | Histone H3 K36me3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I89 | Histone H3 K36ac Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I90 | Histone H3 K37me1 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I91 | Histone H3 K37me2 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I92 | Histone H3 K37me3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I93 | Histone H3 K56me1 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I94 | Histone H3 K56me3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-I95 | Histone H3 K79Me3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| 600-401-J98 | Histone H3 K4-Me3/K9-Ac Antibody | 50ug | Human, mouse, rat, C. elegans |
| 600-401-J99 | Histone H3 K27me3 Antibody | 50ug | Human, mouse, rat, C. elegans |
| 600-401-K00 | Histone H3 K27ac Antibody | 50ug | Human, mouse, rat, C. elegans |
| 600-401-K01 | Histone H3 K4me2/pT6 Antibody | 50ug | Human, mouse, rat, C. elegans |
| 600-401-K02 | Histone H3 K23me2 Antibody | 50ug | Human, mouse, rat, C. elegans |
| 600-401-M75 | Histone H3 K27 methyl Antibody | 50ug | Human, mouse, rat, C. elegans |
| 600-401-P08 | Histone H3 K9-Ac/pS10 (RABBIT) Antibody | 50ug | Human |
| 600-401-P10 | Histone H3 K79-Me1 Antibody | 50ug | Human, Mouse, Primate, C. elegans, Drosophila, Plant, Rat, Xenopus |
| 600-401-P14 | Histone H3 pT3/R2-Me2s Antibody | 50ug | Human |
| 600-401-V34 | Histone H3 K27 me2 Antibody | 50ug | Human |
| 600-401-W54 | Histone H3 K27 me1 Antibody | 50ug | Human |
*以上產(chǎn)品僅供科研使用,不得用于醫(yī)療及診斷.
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